Asaad Babker
Gulf Medical University, United Arab EmiratesPresentation Title:
Genetic mutations influencing recurrent pregnancy loss: A study on factor V leiden, prothrombin G20210A, and MTHFR C677T among Sudanese women
Abstract
Background: Recurrent pregnancy loss (RPL), defined as the occurrence of three or more consecutive pregnancy losses, affects approximately 1-5% of couples of reproductive ages. This condition poses significant emotional distress and confusion, as conventional diagnostic evaluations yield definitive results for less than half of those experiencing multiple losses.
Aim: This study aimed to investigate the association between specific genetic mutations—Factor V Leiden (G1691A), Prothrombin (G20210A), and MTHFR (C677T)—and recurrent pregnancy loss in Sudanese women.
Materials and Methods: A retrospective analytical case-control study was conducted at Omdurman Maternal Hospital in Sudan from July 2013 to July 2015. Ethical approval was secured from the Faculty Research Board and the Hospital of Omdurman Maternity Hospital. The study included 100 pregnant women with a history of recurrent spontaneous abortion (case group) and 95 healthy reproductive age Sudanese women (control group). Data were collected through structured questionnaires and direct interviews. Point mutations in Factor V Leiden (G1691A), Prothrombin (G20210A), and MTHFR (C677T) were identified using polymerase chain reaction. The odds ratios and 95% confidence intervals (95% CI) for the presence of these mutations were calculated and analyzed using SPSS version 17.0.
Results: The frequency of the Prothrombin G20210A and MTHFR C677T mutations was low overall, while the Factor V Leiden G1691A mutation was more prevalent. However, the differences in mutation frequencies between the patient and control groups were not statistically significant (P-value > 0.05).
Conclusion: This study highlights the low prevalence of inherited thrombophilia, including Factor V Leiden, Prothrombin G20210A, and MTHFR C677T, among Sudanese women with recurrent pregnancy loss. These findings suggest that these genetic mutations are unlikely to contribute to the pathogenesis of RPL in this population, indicating the need for further research to explore other potential causes of recurrent pregnancy loss.
Biography
Asaad Mohammed Ahmed Abdallah Babker is a distinguished academic and clinical expert in the field of Hematology and Immunohematology. Born in Sudan in 1981, he obtained his Ph.D. in Medical Laboratory Sciences from Sudan University of Science and Technology in 2015. Currently serving as a Professor at Gulf Medical University in Ajman, UAE, he has garnered extensive experience in teaching, research, and laboratory management. Babker has published over 130 articles in international referred journals, authored four books, and contributed to significant advancements in the understanding of hematological disorders. His research focuses on inherited thrombophilia and recurrent pregnancy loss, contributing to better medical practices in his field. A member of various professional bodies, including the American Society for Clinical Pathology and the European Hematology Association, he is actively involved in improving the quality of medical education and laboratory practice. Babker's commitment to research and education has inspired many students and professionals alike, making him a notable figure in the medical community. He continues to innovate in medical laboratory sciences while providing a mentorship role to future healthcare professionals.
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