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Jaime Ruiz Tovar

Rey Juan Carlos University, Spain

Presentation Title:

Effect of Lactobacillus kefiri, in conjunction with PENS T6 and a hypocaloric diet, on weight loss, hypertension and laboratory glycemic and lipid profile

Abstract

Background: The pathogenesis of obesity has been linked to alterations in gut microorganisms. The aim of this study was to investigate the effect of Lactobacillus kefiri, together with PENS T6 and a hypocaloric diet, on weight loss, hypertension and laboratory glycemic and lipid profile.
Methods: A prospective nonrandomized study was conducted involving adult patients with a body mass index (BMI) > 30 kg/m2. Patients were divided into two groups: those undergoing PENS-T6 and hypocaloric diet (PENS-Diet Group) and those undergoing the same PENS-T6 scheme and hypocaloric diet, but additionally receiving probiotics including Lactobacillus kefiri (PENS-Diet + L. kefiri Group). Weight loss was assessed at the end of the treatment, and analytical glycemic and lipid profile, and microbiological analysis of feces were performed before and after treatment.
Results: 60 patients were included in the study. Significantly greater weight loss and improved glycemic parameters were observed in the PENS-Diet + L. kefiri group. Regarding lipid profile, triglyceride reduction and HDL-cholesterol increase were significantly higher in the PENS-Diet + L. kefiri group. Significant increases in muconutritive microbiota, Akkermansia muciniphila and Lactobacillus spp. were observed in both groups. However, when analyzing the increases separately, it can be determined that the increase was significantly higher in the PENS-Diet + L. kefiri group.
Conclusion: The addition of Lactobacillus kefiri to PENS T6 and a low-calorie diet, increases weight loss and further improves the glycemic and lipid profile. L. kefiri also causes a further improvement in obesity-associated dysbiosis, mainly by increasing the muconutritive (Akkermansia muciniphila) and regulatory (Bifidobacterium spp.) microbiome, and the Phylum Bacteroidetes (Prevotella spp.) and decreasing the Firmicutes/Bacteroidetes ratio.

Biography

Jaime Ruiz-Tovar, MD, PhD, is a general and digestive surgeon at University Hospital Rey Juan Carlos (Madrid, Spain), specializing in bariatric surgery. He is a professor of surgery at Universidad Rey Juan Carlos, secretary of the surgical infections section of the Spanish Surgical Society, and head of the bariatric surgery section of the ERAS-Spain group (Enhanced Recovery After Surgery). He leads several investigational projects focused on bariatric surgery and surgical infections. Dr. Ruiz-Tovar has extensive experience in obesity surgery and nutrition, and he developed the technique of neurostimulation of abdomen dermatomes for appetite control. This procedure involves stimulating the stomach with a minimal voltage electrical current through a fine needle inserted subcutaneously into the abdomen's skin, which is painless. Through 30-minute weekly stimulations over 10 weeks, average weight losses of around 10 kg are achieved, reducing appetite in 95% of cases and supporting compliance with a low-calorie diet in over 90% of patients.