We present the case of a 33-year-old female with a history of epidermolysis bullosa and a diagnosis of right ovarian teratoma, requiring a surgical approach for resection. It was required to administer balanced general anesthesia with nasal intubation by fiberoscopy according to the patient’s clinical conditions. This case highlights the importance of pre-operative assessment, operating room conditioning, and anesthetic planning to manage patients with rare pathologies effectively.

Jéssica Sinsel, an anesthesiologist who recently graduated from the Autonomous University of Nuevo León, Mexico, who throughout her academic training was exposed to various rare cases for which she had to prepare and conduct a literature search to prepare the best approach and with this she discovered the little information there was on certain topics, including the management of the patient with epidermolysis bullosa.