Alpha-gal syndrome (AGS), a delayed type I hypersensitivity reaction to the oligosaccharide galactose-α-1,3- galactose, has emerged as a significant global health concern. This presentation explores recent advancements in our understanding of AGS, with a particular focus on the potential role of parasites in its development. Key points: 1. AGS causes delayed allergic reactions to mammalian meat products and immediate reactions to certain medications like cetuximab. 2. Symptoms range from mild gastrointestinal issues to life-threatening anaphylaxis. 3. While tick bites are the primary known cause of alpha-gal sensitization, recent evidence suggests other parasites may play a role. We present a case study of an 18-year-old woman who experienced anaphylaxis without recent tick exposure. Diagnostic workup revealed alpha-gal sensitization and Ascaris lumbricoides infection. New research findings: 1. Alpha-gal epitopes detected in Ascaris glycoproteins at higher concentrations than in some tick species. 2. Correlation between alpha-gal sIgE and Ascaris sIgE levels in AGS patients. 3. Recombinant ABA-1 protein from Ascaris can activate basophils in AGS patients, suggesting a potential causal role of A. lumbricoides exposure in alpha-gal sensitization and the elicitation of clinical reactivity. These discoveries highlight the complex interplay between parasites and allergic diseases. Alpha-gal syndrome exemplifies the intricate relationships in our immune system. While mast cells, immunoglobulin E, and eosinophils are commonly associated with immediate allergic reactions, their primary evolutionary role was to defend against multicellular parasites. Recent findings underscore the multifaceted nature of AGS and its links to various parasitic infections. This evolving knowledge has significant implications for understanding, diagnosing, and managing allergic diseases, opening new avenues for research in immunology and parasitology. 

Kacper Packi is a specialist in molecular medicine, holding a Ph.D. in medical and health sciences in the field of pharmaceutical sciences. His research focuses primarily on immunology, allergology, and parasitology, with a particular interest in the intricate relationships between parasitic infections and allergic diseases. As an assistant professor at the Medical University of Lodz, Packi has developed expertise in personalized medicine, genetics, and molecular diagnostics. His work, published in reputable international journals, contributes significantly to the scientific understanding of complex immunological mechanisms. Packi's career is marked by his commitment to innovative diagnostic solutions and personalized patient care. A pivotal moment in his career was the establishment of the AllerGen Personalized Medicine Center. This initiative aims to bridge the gap between scientific research and practical healthcare applications, focusing on the promotion and popularization of scientific and research activities. Currently, Packi is leading projects that explore the connections between parasitic infections and allergic responses, contributing valuable insights to the fields of immunology and allergology. His dedication to advancing personalized medicine and promoting scientific research continues to make significant contributions to the field of medicine.