Zachariah Chowdhury
Tata Memorial Hospital, IndiaTitle: Exploring solitary fibrous tumors at a Tertiary Cancer Center: Clinicopathological and immunomorphologic profile
Abstract
Background
Solitary fibrous tumor (SFT) is a distinct fibroblastic tumor that can occur at any anatomical site and can manifest a variety of histopathological features. NAB2-STAT6 gene fusion has recently emerged as a sensitive and specific molecular marker and its surrogate on immunohistochemistry, STAT6 has also displayed considerable efficacy. Nevertheless, its histologic diversity can result in diagnostic challenges, especially when classic features are not apparent.
Material and methods
A retrospective study was conducted at a tertiary cancer centre in North India over 3 years to document the clinicopathologic and immunomorphologic profile of SFTs. Immunohistochemical analysis of BCOR and p53 were gauged additionally and patients were stratified according to Modified Demicco and Salas criteria for risk of metastasis.
Results
Sixteen patients of SFT were identified, affecting middle-aged men and women equally. Though lung/pleura are known to be involved commonly, SFT affects other sites such as the kidney, brain, buccal mucosa, liver, and penis as well. The majority endured localized disease while a lesser number suffered locoregional/distant spread. Two patients revealed features of a malignant profile. Risk stratification according to the modified demicco and Salas criteria evinced comparable results. No discernible relationship however was highlighted between the immunohistochemical expression of BCOR, p53, and any significant SFT parameter.
Conclusion
Although SFTs are very rare substantially benign mesenchymal neoplasms, pathologists must be conversant with their histological diversity and be vigilant of their malignant attributes. The worth of STAT6 immunohistochemistry for precise diagnosis and long-term studies for delineating clinical behavior cannot be overemphasized.
Biography
Dr Zachariah Chowdhury is currently the Associate Professor and Officer-in-charge of the Department of OncoPathology, Mahamana Pandit Madan Mohan Malviya Cancer Centre & Homi Bhabha Cancer Hospital (Tata Memorial Hospital), Varanasi, Uttar Pradesh, India. This tertiary cancer care centre run by the Government of India is one of the prestigious cancer centres in the North of India, a vast densely populated area unfortunately affected by a myriad of cancers. Dr Zachariah is an UICC fellow in OncoPathology from the reputed Tata Memorial Centre Mumbai and completed his post-graduation in pathology in 2011. Thereafter he has worked as a faculty in various tertiary care institutes and is now a dedicated oncopathologist. He has over 5 years of experience in the various aspects of oncopathology including molecular pathology with active interest in the fields of lymphomas, breast pathology, gynae-oncopathology, soft tissue sarcomas and pediatric solid tumors. He has over 30 publications in international medical journals, a reviewer of several journals and invited faculty as speaker and panelist at several national and international conference.
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